Both treatments improve skin quality — but they use very different science. Understanding the difference helps you choose the right treatment for your goals.
Polynucleotides (PN) are DNA fragments derived from salmon or trout DNA that stimulate fibroblast activity deep within the skin. They trigger genuine tissue regeneration — promoting the production of new collagen, elastin and hyaluronic acid from within.
Unlike HA-based products that add hydration directly, polynucleotides instruct your skin cells to produce their own structural proteins. This makes them particularly effective for skin that has lost its regenerative capacity — common in ageing, sun-damaged or scarred skin.
Skin boosters (like Profhilo, Seventy Hyal, and other HA-based products) deliver hyaluronic acid directly into the skin to improve hydration, firmness and overall quality.
They work by attracting and retaining water molecules in the dermis, creating a plumper, more hydrated and luminous complexion. They also stimulate some collagen production, though through a different mechanism than polynucleotides.
• Polynucleotides stimulate tissue regeneration at a cellular level • Skin boosters deliver immediate hydration via hyaluronic acid • Polynucleotides are particularly effective for dark circles, fine lines and scarring • Skin boosters excel at overall hydration, firmness and radiance • Polynucleotides create long-lasting structural improvement • Skin boosters provide more immediate visible improvement • Both require multiple sessions for best results • Both are injectable with minimal downtime
The best choice depends on your primary concern:
• For dark under-eye circles or crepey eye area → Polynucleotides (e.g., Lumi Eyes) • For overall facial hydration and glow → Skin boosters (e.g., Profhilo) • For fine lines and skin texture → Either — or a combination • For ageing, sun-damaged skin → Polynucleotides for regeneration • For dehydrated, dull skin → Skin boosters for immediate improvement
Many clients benefit from both treatments used in combination or alternated throughout the year. During your consultation, we'll assess your skin and recommend the most effective approach.