What Are Polynucleotides? The Regenerative Skin Treatment Explained
Polynucleotides are changing how we think about skin rejuvenation. Learn what they are, how they work, and why they're becoming one of the most requested treatments in aesthetic medicine.
If you've heard the term "polynucleotides" and aren't sure what it means, you're not alone. This is one of the most exciting developments in regenerative aesthetics, but it's also one of the least understood by the general public. Here's a clear, jargon-free explanation.
What Are Polynucleotides?
Polynucleotides (often abbreviated to PN or PDRN) are chains of nucleotides — the building blocks of DNA. In aesthetic medicine, we use purified polynucleotides derived from salmon DNA (which is highly biocompatible with human tissue) to stimulate your skin's natural repair and regeneration processes.
Think of it this way: rather than filling or freezing your skin, polynucleotides give your cells the raw materials and signals they need to repair themselves.
How Do They Work?
When injected into the skin, polynucleotides:
- Stimulate fibroblast activity — the cells responsible for producing collagen and elastin
- Promote tissue regeneration at a cellular level
- Provide deep, lasting hydration by attracting and retaining water in the tissue
- Reduce inflammation — helpful for sensitive or reactive skin
- Improve skin quality — texture, firmness, and overall health
How Is It Different from Profhilo?
Both are injectable skin quality treatments, but they work differently:
- Profhilo uses high-concentration hyaluronic acid to stimulate collagen through bio-remodelling
- Polynucleotides work at a deeper, cellular level — stimulating DNA repair and fibroblast activity
- Many practitioners now use them in combination for comprehensive skin rejuvenation
What We Use at AURA
We use Seventy Hyal — a next-generation polynucleotide skin booster that combines polynucleotides with hyaluronic acid for both immediate hydration and long-term regeneration. It's particularly effective for:
- Under-eye rejuvenation (dark circles, crepey skin)
- Overall skin quality improvement
- Neck and décolletage rejuvenation
- Post-treatment skin recovery
- Menopause-related skin changes
Book a Skin Consultation
Interested in polynucleotides? Book a treatment at AURA and we'll assess your skin quality and recommend the best approach for your concerns.
